There will be 259 total selections over a three-day period . I tweaked my predictions from Sunday to reflect . Read more. Plus, Antonio Brown is angry and wants the ball, which means he's due for a big game. What to know for fantasy: Dalvin Cook has rushed for a touchdown in all four weeks this season and has seen his reception total increase each week as he continues to make a bid as a top-tier fantasy RB. New England's slide has coincided with losing DT Lawrence Guy (shoulder), who might be ready to return. Jets' high-priced, underperforming offensive line receives wake-up call Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', 1 p.m. The advantage for the Packers does not lie so much in the schematics, but the rest, which allowed four key offensive players more time to get ready. Analyzing how, where Golden Tate fits into Giants' offense, 1 p.m. -- Rich Cimini. But let's put the bold in bold prediction. Read more. They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). But the key in this one will be the ability of the Carolina defense to make the Lions one-dimensional and force Matthew Stafford to beat them. So this is a game the Chargers normally would lose, which is why Im picking them to win -- along with the fact that I believe the Giants will have trouble stopping the Bolts talented pass-rushing duo of Melvin Ingram and Joey Bosa. Since 2011, games with totals of 55 or higher are 33-22-1 to the over. If that's the case, the Cardinals could pull off the upset. -- Tim McManus. In that case, at home, Stafford has the edge. The one thing that might help their offense is the return of running back Alvin Kamara, who said he's ready to roll this week. Chargers 20, Giants 19 -- Eric Williams, The Giants are at home in a game they badly need to keep from imploding. The Cardinals have allowed a league-high 20 sacks; the Bengals are right behind them at 19. Walder's pick: Eagles 23, Cardinals 20 Stat to know: The Eagles are the only team to win the turnover battle in every game this season. ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. Walder's pick: Packers 24, Giants 12 Stat to know: The Rams have been outscored 44-3 with an NFL-worst minus-41 point differential in the fourth quarter this season -- they have outscored opponents by 17 in the first three quarters. Veteran WR Cole Beasley retires after 11 NFL seasons, What to watch for: Rookie quarterback Kenny Pickett is set to make his first career start against a Bills defense that is tied with the San Francisco 49ers for giving up the fewest yards per game (234.5). What to know for fantasy: Barkley has more than 20 carries or a rushing TD in all four games this season and leads the league in percentage of team offense accounted for (40.4%). The latest hint that the Jets are destined for the spotlight came from ESPN's Adam Schefter. NFL SPREAD TO WIN TOTAL Philadelphia Eagles -5.5 -227 o49 Arizona Cardinals +5.5 +175 u49 49ers 37, Panthers 15 Point spread: 49ers (-6.5) cover by winning by more than 6.5 points. Jets 24, Browns 10 -- Pat McManamon, The Lions are strong against the run, which makes the timing of Panthers quarterback Cam Newton finding his timing against New England most important. The role is great, but don't forget DeAndre Hopkins' suspension has just two weeks left on it. -- Todd Archer, Bold prediction: The first team to 30 rushing attempts will win. -- Josh Weinfuss, Bold prediction: Arizona will double its sack total on the season and take Jalen Hurts down four times. Davenport's pick: Titans 17, Bills 14 See Week 5 rankings. The Bills and Steelers matchup, discussed in greater detail below, moved from Buffalo minus-8 to Buffalo minus-14, but a perhaps. Betting nugget: All four Bills games have gone under the total this season. 2020 NFL draft order: Top 20 picks -- Mike DiRocco, Bold prediction: Texans wideout Brandin Cooks will have his best outing of the season with a 100-yard game. Jack Driscoll, who hasn't started a game at left tackle since college, has been getting the work on Hurts' blind side this week. Dolphins 19, Titans 17 -- Cameron Wolfe, The Dolphins allowed 235 rushing yards in last year's loss to the Titans. The Vikings are banged up on offense but probably still good enough to squeak out a close victory. See Week 5 rankings. Why Lions GM is getting high praise The Jags likely won't have cornerback Jalen Ramsey, and the domino effect of his absence will be a major issue when McCaffrey lines up on the outside. 1 wideout Jordan Matthews. Including playoffs, Rodgers has thrown 29 touchdown passes with just eight interceptions in 15 games. The Titans' pass defense was a disaster as the Titans gave up 57 points to the Texans in a Week 4 rout. However, Arizona's primary hope for winning this game lies with its run defense. FPI prediction: MIN, 71.6% (by an average of 7.9 points), Matchup must-reads: Jones brings new energy, hope to Giants What's happened to Thielen and Diggs? Watch on ESPN+ More , Bold prediction: Nope. Betting nugget: Baltimore has covered each of the past five meetings in Pittsburgh. Bengals 14, Bills 10 -- Katherine Terrell, Coach Todd Bowles says "2-2 is nothing to brag about." With the return of Michael Gallup, Lamb will have chances to get away from Jalen Ramsey to make more plays. The Raiders . Depth charts for every team Chargers-Saints point spread: Saints -8.0 (over/under 50.0) They have an NFL-best plus-eight turnover margin. Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Stat to know: The Titans have allowed a player to record six or more receptions in each of their four games this season. The Bengals are allowing 8.6 yards per attempt, which is ideal for a team averaging 5.5 despite having Kyler Murray -- who has thrown for 300 yards in two of his first four games. Steelers 24, Jaguars 10 -- Mike DiRocco, The Steelers' offense is poised to break out eventually; Ben Roethlisberger has only one completion of more than 40 yards this season -- which came in Week 2, his only home game. What to know for fantasy: After scoring 11 times in his first 14 games last season, Hopkins has scored just twice in his past seven games (playoffs included). ET | CBS -- Jeff Legwold. -- Mike Reiss, Bold prediction: Lions running back Jamaal Williams will rush for at least two touchdowns. Barshop's pick: Texans 20, Falcons 17 3 all-time rusher Barry Sanders, Meet Brady's most trusted teammate: His 1995 shoulder pads, Redskins' January decision to maintain status quo looks bad in hindsight, Patriots' offense searching for identity, as it did in 2018, Big pass plays tearing up Ravens' defense, 'Do whatever' to win: Steelers bring back the Wildcat, Raiders hoping to reverse London trend by changing travel schedule, Left with no defense, Jackson needs to carry Ravens this season, Steelers' first draft by Khan 'aggressive', Mack expected to be with the Raiders 'for the long haul', Daniel embraces seldom-used, uncertain backup QB life, Carr: Burfict's 'heart is broken;' QB says ban isn't fair, Analyzing how, where Golden Tate fits into Giants' offense. -- Brady Henderson. These two teams played last year in similar circumstances, with the Titans leaving with the victory due to Mariota's four touchdowns and a stout running game. With DT Fletcher Cox still working through a calf injury, there's a chance Palmer will have a little more time to operate. Our experts share their favorite upset picks for Week 5, including an unsuspecting team who is 3-1 to start the year. 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. Bengals 13, Bills 9 -- Mike Rodak, The Bengals have a tough matchup against one of the league's best defenses (Buffalo is 10th overall), but it looks like their offense finally has begun to click in the past two weeks. ET games. ET | CBS That doesnt mean theyll have an easy time against Houston rookie QB Deshaun Watson. ET | Fox Cowboys 27, Packers 23 -- Rob Demovsky, For the second consecutive week, the Cowboys are facing a team with a 10-day break. Three (Tommy Nobis, 1966; Earl Campbell, 1978; Kenneth Sims, 1982) have been selected first overall. Betting nugget: Detroit has covered six straight road games, but it is 0-10-1 outright in its past 11 road games (0-9-1 under Dan Campbell). But Browns RB Nick Chubb leads the NFL in rushing first downs and rushes of 10-plus yards. The Cards are dead last in the league with four sacks entering Week 5. Read more. Read more. The Week 5 NFL slate is stacked with great matchups. Stat to know: The Chiefs have won six straight home games on Monday Night Football with the last loss coming in 2004 against the Patriots. Washington's pass defense is allowing 259.8 yards per game, but 294 yards per game at home. Colts 23, 49ers 20 -- Nick Wagoner, The last thing the Colts can do is overlook the 49ers. FPI prediction: KC, 80.9% (by an average of 12.0 points), Matchup must-reads: Mahomes, Favre and other NFL stars reveal the larger-than-life tales behind Andy Reid Colts GM Chris Ballard has needed his no-flinch, no-panic approach Chiefs RB Williams has waited behind big-name backs before Ebron 'disgusted' by drops, takes blame for Colts' loss, Monday, 8:15 p.m. What to know for fantasy: Curtis Samuel's target share is nearly twice that of DJ Moore (24.1% to 12.1%) with Kyle Allen under center for the Panthers this season. See Week 5 rankings. Experts weigh in with analysis and provide premium picks for upcoming NFL games. The Jaguars were leading the NFL in rush defense until giving up 210 yards and four rushing touchdowns in a loss at Philadelphia last weekend. -- Jenna Laine. Wells' pick: Chiefs 41, Colts 24 (1:17). Atlanta is the only team this season undefeated against the spread. His 43.1 QBR this season is also his worst through the first four games in that same time frame. -- Rich Cimini, Bold prediction: Bridgewater with throw for 300 yards and three touchdowns, including two to Tyreek Hill. What to know for fantasy: Murray leads the NFL with 187 opportunities this season (pass-plus-rush attempts). Moody's pick: Chargers 27, Browns 20 But Joe Flacco's struggles (one touchdown in his past 28 drives) and Baltimore's poor history traveling out west (five consecutive losses) make it difficult to have any confidence in the Ravens. Reiss' pick: Patriots 30, Redskins 6 That stat line would be worth 259.6 points, not much different from the 260.1 points that Allen produced last season. Packers 33, Cowboys 27 -- Todd Archer, The Chiefs are 8-1 against quarterbacks in their first season as starters since Andy Reid arrived as head coach and Bob Sutton as defensive coordinator in 2013. See Week 5 rankings. It ranks in the bottom third of the NFL in yards allowed per carry (5.0), and the Giants -- with the NFL's leading rusher, Saquon Barkley -- run it at the second-best clip in the league (5.8 yards per carry). -- Jake Trotter. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Buccaneers coach Todd Bowles explains handling of TE Cameron Brate's concussion, Veteran WR Cole Beasley retires after 11 NFL seasons, QB Kenny Pickett, Steelers begin work to get on 'same page', The Steelers' 2022 quarterback journey, and what happens next, LB Jamie Collins joins Patriots for fourth time, Swift likely out again vs. Patriots, source says, Bears designate WR N'Keal Harry for return; OL Cody Whitehair headed to IR, Inside Kelly Kleine's historic journey, from Vikings to Broncos, Justin Fields, Bears' struggling passing game looking for answers, Vikings riding ups and downs as Cousins learns new scheme, Dolphins' Mike McDaniel not fretting criticism over Tua Tagovailoa, Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded, Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, Browns' schedule gets difficult from now on, Garrett back at Browns practice for first time since car crash, Everything you need to know for the draft, The Seahawks have needed every bit of Geno Smith's unlikely success, Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start, Saints' Alvin Kamara (rib) expects to play against Seahawks, Titans rookie WR Treylon Burks exits game with leg injury, Rivera OK with 'frustrations' amid 1-3 start, Commanders patient with Wentz despite rough stretch, RB Robinson returns to practice after being shot in robbery attempt, After loss, the Jaguars look to rebound against AFC South, How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL, Former Jaguars QB Blake Bortles says he 'quietly' retired, Jimmie Ward year away from being among rarefied 49ers company, Mayfield struggles, but Panthers don't have another option, Nick Bosa says 49ers' defense has personnel to be 'best in the league', Mayfield takes blame for offense's struggles amid 1-3 start, Darnold's return from IR not close, coach Matt Rhule says, Miles Sanders' emergence makes the Eagles so much better, Defense keeps Cardinals afloat while offense figures it out, Jerry Jones: An 'injustice' not to give coach McCarthy credit. Gutierrez's pick: Bears 20, Raiders 16 Betting nugget: Carolina is 3-15 ATS in its past 18 games. They also rank No. What to know for fantasy: Najee Harris averaged over 4.0 yards per carry for the first time this season last week, but he failed to record a reception in Pickett's NFL debut. FPI prediction: CAR, 56.2% (by an average of 1.8 points), Matchup must-reads: Jimmie Ward year away from being among rarefied 49ers company Mayfield struggles, but Panthers don't have another option Nick Bosa says 49ers' defense has personnel to be 'best in the league' Mayfield takes blame for offense's struggles amid 1-3 start Darnold's return from IR not close, coach Matt Rhule says, 4:25 p.m. He's a bad matchup for the Jaguars because they've had issues covering backs out of the backfield. Read more. Stat to know: Tampa Bay's Shaquil Barrett leads the NFL with 9.0 sacks through four games. 3 all-time rusher Barry Sanders, 1 p.m. ET | ESPN/ESPN App They will welcome back Taylor Lewan from a four-game suspension with open arms. -- Paul Gutierrez. Read more. Stat to know: Jared Goff is tied for the lead in passing touchdowns with 11. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . UPDATE: I made seven changes to my final mock draft -- starting with the No. ET | ESPN After catching eight passes for 111 yards in the season opener, he has not reached 70 receiving yards in any of the past three games. Betting nugget: In the past six London games, favorites are 5-1 ATS, and five of the six games went under the total. Eagles 27, Cardinals 17 -- Josh Weinfuss, Larry Fitzgerald long has tortured the Eagles, averaging six catches, 99 yards and more than a touchdown per game against them in seven meetings. Panthers 24, Lions 21 -- David Newton, Defending Newton will be tough, and linebacker Luke Kuechly could cause Stafford some issues, but the Lions have shown they are one of the better teams in the NFC. Matchup rating: 42.0 | Spread: PHI -14.5 (43.5), What to watch for: The Eagles are paper-thin at cornerback after injuries to Ronald Darby and Avonte Maddox. What to know for fantasy: When you see "Brady vs. Atlanta," you likely think about the Super Bowl comeback, but that's not going to help you. Vikings 27, Bears 26 -- Jeff Dickerson, Cowboys' running game will be tested on Sunday (1:06), Week 5 NFL predictions: Scores for every game, Dolphins' Jaelan Phillips, teammates inspired by mentoring incarcerated teens, What adding Odell Beckham Jr. would mean for the New York Jets, Extending Vikings star Justin Jefferson: what it could cost, possible sticking points. The answer is to be determined, Cruz expects Minshew will lead Jags over Allen's Panthers (1:17), Week 5 NFL game picks, schedule guide, fantasy football tips and more, Which NFL teams still have roster holes? The Week 5 NFL slate is stacked with great matchups. The Bears, however, are the league's least-equipped team to exploit that shortcoming. What to know for fantasy: Baker Mayfield averaged one touchdown pass every 18 attempts as a rookie. Stat to know: Daniel Jones needs two passing touchdowns and 72 passing yards to have the most in each category by a Giants quarterback in his first three NFL starts since the 1970 merger. Super Bowl champs ready for the draft What will help you is the fact that the GOAT is averaging 28.0 PPG as a Buccaneer against the Falcons. See Week 5 rankings. Walder's pick: Chargers 24, Browns 20 There have been 45 Longhorns selected in the first round. Betting nugget: Philadelphia is 3-0 ATS against Pittsburgh since 2008. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. -- Mike Reiss. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. The Colts, meanwhile, are scoring on 40% of their possessions, 11th best. Overall, Minnesota is tied for eighth in points allowed (19.0) and third in rushing yards allowed (71.3). FPI prediction: CIN, 56.2% (by an average of 2.2 points), Matchup must-reads: Cardinals WR Kirk likely out Sunday but ankle better Bengals put WR Ross on IR with shoulder injury, 4:05 p.m. It won't hold, though, as J.J. Watt & Co. make life miserable for the Falcons' offensive line. FPI prediction: LAC, 65.1% (by an average of 5.4 points), Matchup must-reads: Broncos' 'world of suck' won't be easily fixed How Chargers kept team from splintering during Gordon holdout Chubb's injury further exposes Broncos' house of cards, 4:25 p.m. Let's get into the full Week 5 schedule, starting with an NFC South showdown. -- Mike Triplett, Everything you need this week: But Minnesotas defense is tough. With coaching staff in place, what's next for Carolina Panthers? Rams 23, Seahawks 20 -- Alden Gonzalez, The Ravens catch a break with EJ Manuel starting at quarterback for the injured Derek Carr. The Saints' problems are beyond the quarterback right now, as they are among the worst teams in the league in both penalties and turnover differential. -- Sarah Barshop, Bold prediction: CeeDee Lamb will finish with more catches than Cooper Kupp. Their offense is clicking on all cylinders, and their defense finally showed signs of life in the second half Sunday, holding Dallas to a mere six points. Legwold's pick: Chargers 23, Broncos 21 Steelers 27, Jaguars 20 -- Jeremy Fowler, The Seahawks are coming off one of the more dominant halves of football they've played under Pete Carroll, outscoring the Colts 36-3 and holding them to 32 yards in the second half last week. Plus, the Jaguars gave up 256 yards rushing last week to the Jets and now face the league's best back in Le'Veon Bell. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . For the season on third downs, he's completing only 48.9% of his passes and owns a 78.0 passer rating. Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . Around The NFL Podcast Co-Host. San Francisco 49ers Coach Kyle Shanahan, right, talks with quarterback Trey Lance during a Week 4 loss . The Cowboys will want to prove last week was more of a fluke than a trend. It sounds crazy, but the Jets will win their third straight game. Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs Patrick Mahomes says Andy Reid 'stole the show' in TV ad, 9:30 a.m. Matchup rating: 49.4 | Spread: LAC -6.5 (44.5), What to watch for: With Denver desperate for a win and fellow edge rusher Bradley Chubb done for the year because of an ACL injury, look for Von Miller to ignite the Broncos by getting after Philip Rivers, who has limited mobility. The versatile back is now on pace for 115 catches this season. What's more, it's Mayfield at quarterback for the Panthers this time, the same signal-caller Bosa made a point of terrorizing in 2019 with two sacks, a forced fumble and a fumble recovery. NFL expert picks, predictions, lines for Week 5 highlighted by the Giants at Green Bay, Dallas at the Rams, and Las Vegas at Kansas City NFL Expert Picks, Predictions: Week 5 * next to the pick means the team will win, but not cover. NFL picks against the spread for Week 5. Is Jalen Hurts' breakout legit? While the Chargers' running game has struggled, Herbert will always be a threat in the passing game. Commanders patient with Wentz despite rough stretch RB Robinson returns to practice after being shot in robbery attempt, What to watch for: Texans running back Dameon Pierce is coming off the first 100-yard game of his career (which included a 75-yard TD run) and ranks 10th in the NFL in rushing. Read more. Get the latest NFL Week 5 picks from CBS Sports. See Week 5 rankings. Chicago knows how dangerous Minnesota's run game can be, so they'll stack the box to try to take away Dalvin Cook and make Cousins beat them with his arm. Markquese Bell capitalizing on Cowboys opportunity, The 61-0 streak is over: Why the Ravens are no longer the NFL's best closers, Raiders, Josh McDaniels savor first win vs. division rival, former employer Broncos, Mahomes' 'Houdini' play leads Chiefs' bounce-back, Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs, Patrick Mahomes says Andy Reid 'stole the show' in TV ad, Ranking early-season NFL award front-runners: Barnwell picks MVP, OPOY, DPOY, top rookies, 'Believe in yourself': Inside Kelly Kleine's historic rise to executive director of Broncos' football ops, Are the Broncos concerned about Russell Wilson? The 49ers are tied for second in the NFL in sacks with 15 -- which is not a good omen for Mayfield. Tyrod Taylor has excelled in passing to Charles Clay and LeSean McCoy this season, but the Bengals boast the NFL's lowest yards per catch (6.49) by opposing tight ends and running backs.

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